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Related Experiment Video

Updated: Dec 18, 2025

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Incontinence in persons with tuberous sclerosis complex.

Oriana Clasen¹, Justine Hussong¹, Catharina Wagner¹

¹Department of Child and Adolescent Psychiatry, Saarland University Medical Center, Homburg, Germany.

Neurourology and Urodynamics

|June 17, 2020

Summary

This summary is machine-generated.

Tuberous sclerosis complex (TSC) is linked to significant incontinence and psychological issues. Lower adaptive skills correlate with higher incontinence rates in TSC patients, necessitating assessment and treatment.

Keywords:

Developmental Behavior Checklist Vineland Adaptive Behavior Scales daytime urinary incontinence encopresis nocturnal enuresis tuberous sclerosis complex

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Published on: August 14, 2019

Area of Science:

Neurology
Genetics
Developmental Pediatrics

Background:

Tuberous sclerosis complex (TSC) is a genetic disorder affecting multiple systems.
It results from mutations in TSC1 or TSC2 genes, leading to diverse physical and psychological symptoms.

Purpose of the Study:

To investigate the prevalence of incontinence and psychological problems in TSC patients.
To assess adaptive behavior skills in individuals with TSC.
To explore the relationship between incontinence, psychological symptoms, and adaptive functioning.

Main Methods:

Recruited 41 participants (children and adults) with TSC.
Utilized validated questionnaires for incontinence (enuresis/urinary incontinence, fecal incontinence) and psychological symptoms (Developmental Behavior Checklist).
Assessed adaptive behavior using the Vineland Adaptive Behavior Scales (3rd edition).

Main Results:

High rates of incontinence were observed: 60.0% nocturnal enuresis, 51.3% daytime urinary incontinence, and 52.4% fecal incontinence.
Clinically relevant psychological symptoms were present in 65.4% of children and 50.0% of adults.
Incontinence prevalence was significantly higher in participants with lower adaptive behavior composite scores, and psychological symptoms were associated with incontinence subtypes.

Conclusions:

A significant portion of TSC patients experience incontinence and psychological symptoms.
Impaired adaptive skills are linked to increased incontinence in TSC.
Early assessment and intervention for incontinence and psychological issues are crucial for improving daily functioning and well-being in TSC patients.