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[Pancreatico-biliary secretion in enteral hyperoxaluria]
1Medizinisch-Poliklinischen Institutes, Karl-Marx-Universität, Leipzig.
Deutsche Zeitschrift Fur Verdauungs- Und Stoffwechselkrankheiten
|January 1, 1988
Summary
Increased oxalic acid absorption in gastroenterological diseases is linked to bile acid malabsorption. A decreased dihydroxy-trihydroxy-bile acid ratio over 20% indicates hyperoxaluria, but pancreatic lipase activity showed no correlation.
Area of Science:
- Gastroenterology
- Nephrology
- Metabolic Disorders
Context:
- Gastroenterological diseases are frequently associated with increased intestinal absorption of oxalic acid.
- Hyperoxaluria, a condition characterized by elevated urinary oxalate levels, can lead to kidney stone formation.
- The pathogenesis of hyperoxaluria involves the malabsorption of bile acids and fats.
Purpose:
- To investigate the relationship between enteric absorption of oxalic acid and bile acid profiles in patients with various gastroenterological diseases.
- To determine if altered bile acid composition contributes to hyperoxaluria.
- To explore the correlation between oxalic acid excretion and pancreatic lipase activity.
Summary:
- Enteric absorption of 14C-labelled oxalic acid was measured in 49 patients.
- A significantly decreased dihydroxy-trihydroxy-bile acid ratio was observed in patients with hyperoxaluria (exceeding 20% of ingested dosage).
- No correlation was found between oxalic acid excretion and intraduodenal pancreatic lipase activity.
Impact:
- This study highlights the role of bile acid malabsorption in the pathogenesis of hyperoxaluria in gastroenterological patients.
- Findings suggest that altered bile acid ratios are a key indicator of increased oxalic acid absorption.
- Further research into bile acid-targeted therapies may be beneficial for managing hyperoxaluria.