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A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
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Symptomatic Aortic Mural Thrombus Treatment and Outcomes
Ottavia Borghese1, Angelo Pisani2, Isabelle Di Centa1
1Department of Vascular and Endovascular Surgery, Foch Hospital, Suresnes, France.
Annals of Vascular Surgery
|June 20, 2020
Summary
Primary aortic mural thrombus (PAMT) is a rare cause of embolism. Aggressive treatment including anticoagulation and surgical exclusion of the thrombus is effective in preventing recurrence and improving outcomes.
Area of Science:
- Vascular Surgery
- Cardiovascular Medicine
- Thrombosis Research
Background:
- Symptomatic aortic mural thrombus is an uncommon cause of arterial embolism.
- Management guidelines for primary aortic mural thrombus (PAMT) are lacking.
- This study reports outcomes from a single institution's experience with PAMT.
Purpose of the Study:
- To evaluate the treatment results for symptomatic primary aortic mural thrombus.
- To identify effective management strategies for PAMT.
- To assess outcomes and recurrence rates following interventions for PAMT.
Main Methods:
- Retrospective analysis of 97 patients with ischemic events.
- Inclusion criteria: patients with PAMT as the source of embolism.
- Surgical treatment data from January 2011 to December 2018.
Main Results:
- Nine patients (mean age 51) had PAMT, with 33.3% experiencing renal embolism.
- Thrombi were located in the thoracic, visceral, or infrarenal aorta.
- At 22-month follow-up, 44.4% recovered well, while 55.5% had recurrences requiring re-intervention.
Conclusions:
- Primary aortic mural thrombus is an infrequent cause of embolism with no established treatment guidelines.
- An aggressive approach combining anticoagulation and surgical thrombus exclusion appears effective.
- Immediate exclusion of PAMT is associated with the best outcomes and absence of recurrence.
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