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Cerebral Venous Thrombosis Associated with COVID-19
D D Cavalcanti1, E Raz2, M Shapiro1
1From the Departments of Radiology (D.D.C., E.R., M.S., S.D., R.J., A.R., P.K.N.).
Young patients with COVID-19 experienced severe cerebral venous thrombosis, a rare but fatal complication. This highlights the need for awareness of neurological symptoms in coronavirus disease 2019 patients.
Area of Science:
- Neurology
- Infectious Diseases
- Vascular Medicine
Background:
- Coronavirus disease 2019 (COVID-19) is primarily associated with respiratory, cardiac, and renal complications.
- Thromboembolic events are increasingly recognized as a significant complication of COVID-19.
Observation:
- A series of three young patients (<41 years) with confirmed Severe Acute Respiratory Syndrome coronavirus 2 (SARS-Cov-2) infection presented with neurological symptoms.
- These patients developed cerebral venous system thrombosis within days of COVID-19 symptom onset.
Findings:
- Cerebral venous thrombosis involved both superficial and deep systems, including the straight sinus, vein of Galen, and internal cerebral veins.
- Two patients experienced hemorrhagic venous infarcts, and one had deep medullary vein thrombosis.
- All three patients had a fatal outcome, underscoring the severity of this manifestation.
Implications:
- Cerebral venous thrombosis is a rare but severe and potentially fatal neurological complication of COVID-19.
- Clinicians should maintain a high index of suspicion for atypical neurological presentations, including cerebral venous thrombosis, in COVID-19 patients.
- Early recognition and management of cerebral venous thrombosis are crucial for improving outcomes in patients with COVID-19.
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