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Construction and application of textile-based tissue engineering scaffolds: a review
Yongjie Jiao1, Chaojing Li, Laijun Liu
1Key Laboratory of Textile Science and Technology of Ministry of Education and College of Textiles, Donghua University, Shanghai 201620, China. lcj@dhu.edu.cn wanglu@dhu.edu.cn.
Biomaterials Science
|June 20, 2020
Summary
This review highlights how fabric structure design is crucial for textile-based scaffolds in tissue engineering (TE). Optimizing textile structures enhances cell behavior and tissue regeneration, improving scaffold performance for medical applications.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Textile Engineering
Background:
- Tissue engineering (TE) scaffolds are vital for cell growth and mechanical support in tissue/organ repair.
- Medical textiles are promising TE scaffolds, but their full potential is limited by a lack of focus on fabric structure diversity.
- Scaffold properties like composition, morphology, structure, and mechanics critically influence restorative effects.
Purpose of the Study:
- To review textile-based scaffolds for tissue engineering.
- To emphasize the significance of fabric design in TE scaffolds.
- To explore how fabric structure influences cell behavior and extracellular matrix reconstruction.
Main Methods:
- Review of existing literature on textile-based scaffolds for tissue engineering.
- Analysis of fabric structures created by various textile techniques.
- Summarization of structure-property relationships and mechanical behavior of textile scaffolds.
- Discussion of advanced structural design concepts, including profiled fibers and complex textile structures.
Main Results:
- Fabric structure significantly impacts cell behavior and extracellular matrix reconstruction in TE scaffolds.
- Various textile techniques yield diverse fabric structures with distinct mechanical properties suitable for different tissue repairs.
- Understanding structure-property relationships is key to optimizing textile scaffolds for enhanced tissue regeneration.
Conclusions:
- Structural design is a critical, often overlooked, factor in developing effective textile-based TE scaffolds.
- Tailoring fabric architecture can unlock the full potential of medical textiles in regenerative medicine.
- Future prospects include utilizing advanced textile structures and profiled fibers to create superior scaffolds for tissue regeneration.
