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Updated: Dec 18, 2025

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Published on: March 1, 2024
Psoriasis affects self-perception of stress negatively: A prospective, case-control study
Ezgi Aktaş Karabay1, Neslihan Fişek İzci1, Berna Aksoy1
1Department of Dermatology, Bahçeşehir University Faculty of Medicine, Istanbul, Turkey.
This study found higher perceived stress levels in psoriasis patients compared to controls. Managing stress may improve psoriasis treatment outcomes.
Area of Science:
- Dermatology
- Psychiatry
Background:
- Stress is a suspected factor in psoriasis development and worsening.
- Limited prospective research exists on the stress-psoriasis association.
Purpose of the Study:
- To assess perceived stress, depression, and anxiety in psoriasis patients.
- To compare these psychological profiles between patients and healthy controls.
Main Methods:
- 195 psoriasis patients and 114 controls were enrolled.
- Psoriasis severity was measured using body surface area and Physician Global Assessment (PGA).
- Validated questionnaires assessed Dermatology Life Quality Index, Perceived Stress Scale (PSS), Beck Depression Inventory, and Beck Anxiety Inventory.
Main Results:
- Psoriasis patients exhibited significantly higher PSS scores than controls.
- Patients with psoriasis showed higher perceived self-efficacy (PSE) scores.
- PSE scores positively correlated with PGA, indicating a link between self-efficacy and disease severity.
Conclusions:
- The findings support a significant role for stress in psoriasis.
- Identifying and managing stress is crucial for enhancing psoriasis treatment strategies.
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