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Related Experiment Video

Updated: Dec 18, 2025

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing
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Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing

Published on: March 13, 2013

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Tools for quantitative analysis: The Al Yergey perspective.

P Jane Gale1, Mark W Duncan2

  • 1ASMS Archivist/Historian & Gale-Bentz Consulting, Southborough, Massachusetts, USA.

Journal of Mass Spectrometry : JMS
|June 20, 2020
PubMed
Summary
This summary is machine-generated.

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Achieving reliable quantitative mass spectrometry requires careful attention to fundamental principles. This work revisits and updates key concepts for accurate and precise multicomponent quantification, honoring Al Yergey's contributions.

Area of Science:

  • Analytical Chemistry
  • Biochemistry
  • Chemical Engineering

Background:

  • Mass spectrometry is a powerful tool for sensitive and precise multicomponent quantification.
  • However, quantitative data from mass spectrometry are not inherently accurate or precise.
  • Method development requires careful consideration of sample properties and assay goals.

Purpose of the Study:

  • To revisit and update fundamental principles of quantitative mass spectrometry.
  • To highlight critical concerns for obtaining valid quantitative results.
  • To acknowledge the significant contributions of Al Yergey to the field.

Main Methods:

  • Review and update of established principles in quantitative mass spectrometry.
  • Incorporation of insights from a decade-long American Society for Mass Spectrometry (ASMS) Short Course.
Keywords:
accuracyfitness-for-purposeprecisionquantificationquantitative mass spectrometry

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Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing
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  • Focus on critical factors influencing data accuracy and precision.

    • Main Results:

    • Quantitative mass spectrometry requires rigorous adherence to specific principles for reliability.
    • Ignoring critical concerns can lead to misleading or invalid quantitative data.
    • Al Yergey's contributions significantly advanced the understanding and practice of quantitative analysis.

    Conclusions:

    • Valid quantitative mass spectrometry results are achievable with careful attention to methodology.
    • Understanding and applying core principles are essential for accurate multicomponent quantification.
    • The legacy of Al Yergey continues to influence best practices in mass spectrometry analysis.