Anticancer Perspectives on the Fungal-Derived Polyphenolic Hispolon

Area of Science:

• Natural Product Chemistry
• Pharmacology
• Oncology

Background:

• Chemotherapy is a vital cancer treatment, but side effects necessitate novel therapeutic strategies.
• Natural products and their derivatives are being explored for targeted cancer therapy with reduced toxicity.
• Hispolon (HIS), a fungal-derived polyphenol, is emerging as a promising anticancer agent.

Purpose of the Study:

• To review the anticancer effects of Hispolon (HIS).
• To explore HIS's potential as a lead compound for developing new anticancer drugs.

Main Methods:

• Comprehensive literature search using PubMed, ScienceDirect, MedLine, Web of Science, and Google Scholar.
• Keywords included 'Hispolon' combined with terms related to cancer, cytotoxicity, cell cycle, apoptosis, metastasis, migration, invasion, proliferation, genotoxicity, drug resistance, autophagy, and estrogen receptor.

Main Results:

• Hispolon demonstrates anticancer activity by modulating key molecular pathways, including cell cycle arrest, apoptosis, and autophagy.
• HIS inhibits cancer cell proliferation, metastasis, migration, and invasion.
• Hispolon exhibits chemopreventive properties and inhibits estrogenic activity, with potential anti-inflammatory effects.

Conclusions:

• Hispolon and its derivatives show promise as anticancer agents.
• These natural compounds could serve as leads for developing novel plant-based chemotherapeutic drugs.
• HIS may be used alone or in combination with existing chemotherapy agents.