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Platelet parameters in Chinese older adults with metabolic syndrome
Xue-Jiao Yang1, Le-Yang Zhang2, Qing-Hua Ma3
1School of Public Health, Medical College of Soochow University, Suzhou, China.
Insights
Platelet count, plateletcrit, and platelet distribution width were higher in older adults with metabolic syndrome. These platelet parameters may aid in assessing metabolic syndrome risk in the elderly.
Area of Science:
- Gerontology
- Hematology
- Metabolic Diseases
Background:
- Metabolic syndrome is a growing concern in aging populations.
- Platelet parameters are increasingly recognized for their role in various health conditions.
Purpose of the Study:
- To investigate the association between platelet parameters and the presence of metabolic syndrome.
- Focus on community-dwelling older Chinese adults.
Main Methods:
- Utilized data from the Weitang Geriatric Diseases Study (4338 participants, aged ≥60).
- Metabolic syndrome defined by Adult Treatment Panel III criteria.
- Platelet parameters analyzed using automated hematology analyzer; logistic regression models employed.
Main Results:
- Elevated platelet count, plateletcrit, and platelet distribution width correlated with higher odds of metabolic syndrome.
- Platelet distribution width association was significant in hypertensive and non-diabetic individuals.
- Platelet distribution width increased with metabolic syndrome risk in men, but not in women.
Conclusions:
- Platelet count, plateletcrit, and platelet distribution width may serve as potential biomarkers for metabolic syndrome risk.
- These findings suggest utility in risk appraisal for metabolic syndrome in the elderly population.
Purpose:
We aimed to examine the associations of platelet parameters with the presence of metabolic syndrome in community-dwelling older Chinese adults.
Methods:
Study sample was from the Weitang Geriatric Diseases Study, which included 4338 individuals aged 60 years or above. The mean age of the participants was 68 years. Metabolic syndrome was defined based on the Adult Treatment Panel III criteria. Platelet parameters were assessed using an automated hematology analyzer. Multiple logistic regression models were fitted to examine relationships between the platelet parameters and the presence of metabolic syndrome after adjusting for potential confounders.
Results:
The adjusted odds ratio (95% CI) of metabolic syndrome for the highest quartile of platelet parameters (platelet count, mean platelet volume, plateletcrit, platelet distribution width, platelet larger cell ratio) when compared to the lowest quartile were 1.32 (1.06, 1.64), 1.00 (0.81, 1.24), 1.37 (1.10, 1.71), 1.45 (1.14, 1.83), 1.11 (0.89, 1.39), respectively. Hypertension and diabetes modified the relationship between platelet distribution width and metabolic syndrome with the associations being significant in hypertensive and non-diabetic groups. The levels of platelet distribution width increased with the risk of metabolic syndrome in men but not in women.
Conclusion:
The levels of platelet count, plateletcrit and platelet distribution width increased in older adults with metabolic syndrome, suggesting that these parameters may be useful biomarkers for further risk appraisal of metabolic syndrome in aged population.
