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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
Genetic Lingo01:11

Genetic Lingo

Overview

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Related Experiment Video

Updated: Jun 16, 2026

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

Intrinsic Capacity, Polygenic Risk Score, and Risk of Glaucoma.

Jia-Yan Kai1, Shi-Yi Gong1, Yu-Hui Hu1

  • 1School of Public Health, Suzhou Medical College of Soochow University, Suzhou, People's Republic of China.

Translational Vision Science & Technology
|June 15, 2026
PubMed
Summary
This summary is machine-generated.

Maintaining intrinsic capacity (IC) is crucial for preventing glaucoma. Impaired IC significantly elevates glaucoma risk, suggesting IC assessment as a key preventative strategy.

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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Related Experiment Videos

Last Updated: Jun 16, 2026

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Area of Science:

  • Ophthalmology
  • Gerontology
  • Public Health

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Intrinsic capacity (IC) encompasses an individual's physical and cognitive capacities.
  • Understanding factors influencing glaucoma risk is vital for prevention.

Purpose of the Study:

  • To investigate the prospective association between intrinsic capacity (IC) and the risk of developing glaucoma.
  • To determine if a deficit in IC components increases glaucoma incidence.
  • To explore potential interactions between IC and genetic predisposition for glaucoma.

Main Methods:

  • Prospective cohort study of 397,881 UK Biobank participants.
  • Construction of an IC deficit composite score based on six components.
  • Cox proportional hazards models used to assess associations with glaucoma risk, adjusting for polygenic risk scores (PRS) and conventional factors.

Main Results:

  • Each 1-point increase in IC score was linked to a 12% higher glaucoma risk (HR=1.12).
  • Individuals with ≥4 IC deficits had a 65% increased risk of glaucoma compared to those with none (HR=1.65).
  • Population attributable fraction analysis indicated 12.0% of glaucoma cases could be prevented by optimizing IC.

Conclusions:

  • Impaired intrinsic capacity is significantly associated with an increased risk of glaucoma.
  • Maintaining and nurturing IC is a valuable strategy for glaucoma prevention.
  • Assessing IC may aid in early glaucoma identification and prevention in clinical and public health settings.