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Related Experiment Video

Updated: Dec 17, 2025

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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Pachymetry and Elevation Back Map Changes in Keratoconus Patients After Crosslinking Procedure.

Melisa Ahmedbegovic Pjano1, Alma Biscevic1,2, Senad Grisevic1

  • 1Eye Clinic "Svjetlost", Sarajevo, Bosnia and Herzegovina.

Medical Archives (Sarajevo, Bosnia and Herzegovina)
|June 25, 2020
PubMed
Summary

Corneal crosslinking (CXL) significantly alters keratoconus patient pachymetry within 12 months, with initial thinning followed by a slight increase. Elevation changes were not statistically significant, indicating CXL

Keywords:
corneal cross-linkingelevation back mapkeratoconuspachymetry

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Biomaterials Science

Background:

  • The standard Dresden protocol for corneal crosslinking (CXL) is the established gold standard treatment for progressive keratoconus.
  • Keratoconus is a progressive condition characterized by thinning and bulging of the cornea.

Purpose of the Study:

  • To correlate changes in corneal pachymetry and elevation back map (EBM) in keratoconus patients 3 to 12 months post-CXL.
  • To assess the long-term efficacy of CXL in stabilizing keratoconus progression.

Main Methods:

  • Analysis of 44 eyes from 34 keratoconus patients who underwent standard Dresden protocol CXL.
  • Preoperative and 12-month follow-up examinations using Oculus Pentacam (Scheimpflug technology) to measure pachymetry and EBM changes.

Main Results:

  • Corneal pachymetry showed statistically significant changes at 3, 6, and 12 months post-CXL, with initial thinning and a subsequent increase.
  • Elevation back map (EBM) differences between preoperatively and 12 months postoperatively were not statistically significant.

Conclusions:

  • Corneal crosslinking leads to significant, albeit dynamic, changes in corneal pachymetry in keratoconus patients.
  • The lack of statistically significant changes in EBM suggests that CXL effectively halts or prevents the progression of keratoconus, as indicated by stable corneal elevation.