Related Experiment Video
Updated: Dec 17, 2025
06:35
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
7.5K
Generalized granuloma annulare associated with essential thrombocythemia
Sai P Polineni1, Steven Lawyer2
1University of Miami Miller School of Medicine Miami Florida.
Clinical Case Reports
|June 25, 2020
Summary
This study reports the first case of granuloma annulare (GA) in a patient with essential thrombocythemia (ET), a myeloproliferative neoplasm. Investigating the link between ET, CML, and GA may reveal new treatment strategies.
Area of Science:
- Hematology
- Dermatology
- Oncology
Background:
- Granuloma annulare (GA) is a benign inflammatory skin condition.
- Chronic myelogenous leukemia (CML) is the only myeloproliferative neoplasm (MPN) previously associated with GA.
- Essential thrombocythemia (ET) is another MPN characterized by elevated platelet counts.
Observation:
- This report details the first documented instance of generalized granuloma annulare (GA) occurring in a patient diagnosed with essential thrombocythemia (ET).
Findings:
- The association between GA and ET suggests a potential link between these conditions beyond the previously established connection with CML.
- This case expands the spectrum of MPNs associated with GA.
Implications:
- Further research into the shared pathophysiology of GA in patients with ET and CML could elucidate the underlying mechanisms of GA.
- Understanding these connections may lead to improved diagnostic approaches and targeted therapies for granuloma annulare.
Related Concept Videos
01:25Endocarditis II: Clinical Features of Infective Endocarditis
261
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
261
01:31Pulmonary Tuberculosis III
789
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
789
01:23Rheumatic Heart Disease I: Introduction
314
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
314
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
320
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
320
01:21Myocarditis I: Introduction
256
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
256
01:28Pulmonary Tuberculosis II
1.2K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.2K