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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Faecal calprotectin in dermatology practice.

V Premjeyanth1, A R Shipman2, K E Shipman3

  • 1Southampton Medical School, Southampton University, UK.

Clinical and Experimental Dermatology
|June 25, 2020
PubMed
Summary

Faecal calprotectin (FCP) shows promise as a non-invasive tool for assessing intestinal inflammation in patients with inflammatory bowel disease (IBD). This review explores its potential role in managing IBD-associated skin conditions.

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Area of Science:

  • Gastroenterology
  • Dermatology
  • Clinical Diagnostics

Background:

  • Inflammatory bowel disease (IBD), encompassing Crohn disease and ulcerative colitis, is a chronic inflammatory bowel condition.
  • Extraintestinal manifestations are frequent in IBD, with dermatological lesions being the second most common after musculoskeletal issues.
  • Traditional IBD diagnosis relies on colonoscopy and biopsy, but non-invasive biomarkers are increasingly important.

Purpose of the Study:

  • To review the utility of fecal calprotectin (FCP) measurement in patients presenting with cutaneous manifestations linked to inflammatory bowel disease.
  • To evaluate FCP as a potential diagnostic and monitoring tool for intestinal inflammation in the context of IBD-related skin conditions.

Main Methods:

  • Literature review of studies investigating fecal calprotectin (FCP) in inflammatory bowel disease (IBD).
  • Analysis of FCP's sensitivity and specificity for detecting intestinal inflammation.
  • Exploration of the correlation between FCP levels and dermatological manifestations in IBD patients.

Main Results:

  • Fecal calprotectin (FCP) is a sensitive and specific biomarker for intestinal inflammation in IBD.
  • FCP has emerged as a valuable non-invasive tool for diagnosing and monitoring IBD.
  • The role of FCP in managing IBD-associated dermatological conditions requires further investigation.

Conclusions:

  • Fecal calprotectin (FCP) is a reliable indicator of intestinal inflammation in inflammatory bowel disease (IBD).
  • Further research is needed to establish the specific role and clinical utility of FCP measurement in patients with IBD-related skin manifestations.