Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

1.1K
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:  
1.1K
Stereotypes, Prejudice, and Discrimination02:55

Stereotypes, Prejudice, and Discrimination

94.6K
Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who...
94.6K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

36.5K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.5K
Epigenetic Regulation01:37

Epigenetic Regulation

3.6K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.6K
Epigenetic Regulation01:46

Epigenetic Regulation

33.2K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.2K
Nondisjunction01:21

Nondisjunction

4.6K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-Esteem, Racial Identity, and Depression in the Long-Term Impact of Discrimination on Health among Black Americans.

Journal of health and social behavior·2026
Same author

Racial discrimination accelerates age-related increases in serum neurofilament light chain among African American women: examination of change from midlife to older adulthood.

The journals of gerontology. Series B, Psychological sciences and social sciences·2026
Same author

Beyond the Strong Black Woman: the Protective Role of Black Identity Centrality against Depression in Young Black Women.

Journal of racial and ethnic health disparities·2026
Same author

Developing Topics.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Elevated Alcohol Consumption and Chronic Inflammation Predict Cardiovascular Risk Among Black Americans: Examination of a Dual-Risk Model Using Epigenetic Risk Markers.

Epigenomes·2025
Same author

Biological aging and its association with serum neurofilament light chain levels in middle-aged African Americans: a prospective observational study.

Aging advances·2025
Same journal

Tissue MicroRNAs in Arrhythmogenic Cardiomyopathy: A Systematic Review of Studies in Human Myocardium and Animal Models with Implications for Post-Mortem Molecular Diagnostics.

Genes·2026
Same journal

Genetic Variants and Dental Caries Susceptibility: An Umbrella Review and Multilevel Meta-Analysis.

Genes·2026
Same journal

Generative AI and Language Models in Human Genetics and Health: From Variant Interpretation to Clinical Decision Support.

Genes·2026
Same journal

Familial White-Sutton Syndrome Caused by a Pathogenic POGZ p.Arg508* Variant: Intrafamilial Variability from Childhood to Adulthood.

Genes·2026
Same journal

Genetic Influence on LDL-Cholesterol Levels: Role of Polygenic Risk Scores and Lp(a) Beyond Monogenic Hypercholesterolemia.

Genes·2026
Same journal

THBS1 as a Key Regulator of Myoblasts: Validation of Its Inhibitory Roles in Skeletal Muscle Development.

Genes·2026
See all related articles

Related Experiment Video

Updated: Dec 17, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.9K

Array-Based Epigenetic Aging Indices May Be Racially Biased.

Robert Philibert1,2, Steven R H Beach3, Man-Kit Lei3

  • 1Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.

Genes
|June 26, 2020
PubMed
Summary
This summary is machine-generated.

Epigenetic aging (EA) indices may be confounded by ethnicity. DNA methylation patterns in newborns and adults show significant ethnic-specific influences, potentially biasing cross-race health outcome comparisons.

Keywords:
DNA methylationepigenetic agingepigeneticshealthcare disparities

More Related Videos

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.5K
The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

9.9K

Related Experiment Videos

Last Updated: Dec 17, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.9K
Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.5K
The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

9.9K

Area of Science:

  • Genetics
  • Epigenetics
  • Biostatistics

Background:

  • Epigenetic aging (EA) indices are widely used to predict health outcomes and mortality.
  • Commonly used array-based EA indices possess heritable components that may correlate with ethnicity.
  • This ethnic component could confound comparisons of EA across diverse racial and ethnic groups.

Purpose of the Study:

  • To investigate whether DNA methylation patterns used in epigenetic aging indices are associated with ethnicity.
  • To determine if ethnic-specific methylation sites identified in newborns are also linked to genetic ancestry in adults.

Main Methods:

  • Examined DNA methylation at 513 probes of the Levine PhenoAge index in cord blood from 203 newborns (African American and White).
  • Analyzed methylation sites associated with ethnicity in newborns for association with European ancestry in 505 African American adults.

Main Results:

  • Fifty CpG sites in newborn cord blood showed significant methylation differences associated with ethnicity after Bonferroni correction.
  • The top five methylation sites predicted ancestry with high accuracy (AUC=0.97).
  • Eleven of the top 50 ethnicity-associated sites in newborns were also linked to European ancestry in adult African Americans.

Conclusions:

  • The Levine PhenoAge Index is influenced by ethnicity-specific genetic factors.
  • Similar epigenetic aging indices may also be affected by these cryptic influences.
  • These findings suggest potential bias in cross-race comparisons of epigenetic aging and associated health outcomes.