[COVID-19 - A RECENT REVIEW]

Uriel Levinger1

  • 1Corona Department, Laniado Hospital.

Harefuah
|June 26, 2020
PubMed

Insights

The novel coronavirus disease (COVID-19) emerged in late 2019, causing severe respiratory illness and thromboembolic events. Current treatments focus on supportive care, with limited success for antiviral therapies.

Area of Science:

  • Medicine
  • Virology
  • Public Health

Background:

  • COVID-19, a novel SARS-like viral disease, emerged in late 2019 in Wuhan, China.
  • Characterized by high transmissibility and severe respiratory distress, it rapidly spread globally.
  • Early reports indicated ARDS-like symptoms, oxidative disruption, and a high mortality rate, overwhelming healthcare systems.

Purpose of the Study:

  • To review the clinical presentation and pathological findings of COVID-19.
  • To discuss the challenges and current understanding of treatment strategies for the disease.
  • To highlight the enigma surrounding effective therapeutic interventions.

Main Methods:

  • Review of initial medical reports and post-mortem findings.
  • Analysis of clinical observations from affected regions, including Italy and Spain.
  • Examination of emerging treatment protocols and drug trial outcomes.

Main Results:

  • COVID-19 presents with severe oxidative disruption and thromboembolic complications, distinct from typical ARDS.
  • Myocardial involvement, including myocarditis and heart attacks, has been reported.
  • Antiviral treatments like Remdesivir have shown limited success in clinical trials.

Conclusions:

  • The primary treatment for COVID-19 relies on comprehensive respiratory, hematologic, nephrologic, and cardiologic support.
  • Significant gaps remain in understanding the disease's pathophysiology and developing effective treatments.
  • Further research is crucial to unravel the complexities of COVID-19 and identify targeted therapies.
Abstract

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