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Updated: Dec 17, 2025

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Linear Alternating Supramolecular Photosensitizer for Enhanced Photodynamic Therapy
1Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Abstract:
Supramolecular polymers with facile and versatile architectures via noncovalent connection present great potential in biological fields. Herein, a linear alternating supramolecular polymer is constructed via host-guest inclusion interaction between cyclodextrin dimer (CD2) and bifunctional adamantane-conjugated porphyrin (TPP-Ad2). The supramolecular alternating structure of CD/TPP could not only suppress the aggregation of PSs to improve the photophysical properties because of the steric hindrance but also enhance the water solubility of PSs induced from cyclodextrin moieties. The nanoplatform obtained by this linear alternating supramolecular polymer (TPP-Ad2/CD2) presents significantly enhanced photodynamic therapy (PDT) efficacy, providing a promising path for PDT.
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