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Updated: Dec 17, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Novel Agents Beyond Immunomodulatory Agents and Phosphoinositide-3-Kinase for Follicular Lymphoma

Collin K Chin1, Loretta J Nastoupil1

  • 1Department of Lymphoma/Myeloma, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 0429, Houston, TX 77030, USA.

Hematology/Oncology Clinics of North America
|June 27, 2020
PubMed

Follicular lymphoma is the most common indolent non-Hodgkin lymphoma. Although median overall survival rates exceed 12 years with rituximab, follicular lymphoma remains largely incurable. The growing understanding of the molecular drivers of lymphomagenesis and the tumor microenvironment have led to novel therapies. Prognostic markers have identified a subset of patients with chemoresistant and/or refractory disease-associated poor outcomes. We identify the patients with follicular lymphoma in need of novel therapies, describe the drivers of lymphomagenesis and importance of the tumor microenvironment, and summarize the novel agents under investigation in relapsed/refractory and upfront follicular lymphoma.

Keywords:
Antibody-drug conjugatesBCL2 inhibitorsBispecific antibodiesCheckpoint inhibitorsEpigenetic therapiesFollicular lymphomaNovel agentsPOD24

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