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Updated: Dec 17, 2025
Simultaneous Eye Tracking and Single-Neuron Recordings in Human Epilepsy Patients
Published on: June 17, 2019
A Second Population-Based Cohort Study in Cameroon Confirms the Temporal Relationship Between Onchocerciasis and
Cédric B Chesnais1, Charlotte Bizet1,2, Jérémy T Campillo1
1UMI 233, Institut de Recherche pour le Développement (IRD), Université Montpellier, INSERM Unité 1175, Montpellier, France.
Abstract:
To confirm our earlier evidence of a temporal and dose-response relationship between onchocerciasis and epilepsy, we conducted another cohort study in a different setting in Cameroon. Individuals whose Onchocerca volvulus microfilarial density (Ov-MFD) was measured in 1992-1994 when they were children were revisited in 2019 to determine if they acquired epilepsy. With reference to individuals with no microfilariae in 1992-1994, the relative risks of acquiring epilepsy were 0.96, 2.76, 3.67, and 11.87 in subjects with initial Ov-MFD of 1-7, 8-70, 71-200, and > 200 microfilariae per skin snip, respectively. This study further demonstrates reproducibility using the Bradford Hill's criteria for causality.
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