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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers
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Drug Loading in Poly(butyl cyanoacrylate)-Based Polymeric Microbubbles.

Mengjiao Liu1, Anshuman Dasgupta1, Patrick Koczera1,2

  • 1Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Aachen 52074, Germany.

Molecular Pharmaceutics
|June 27, 2020
PubMed
Summary
This summary is machine-generated.

Microbubbles (MB) effectively deliver drugs, with loading and release influenced by drug properties like hydrophobicity and molecular weight, especially for similar drug structures. Ultrasound (US) efficiently destroys all MB formulations.

Keywords:
PBCAcorticosteroidsdrug deliverymicrobubblestheranosticsultrasound

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Ultrasound Technology

Background:

  • Microbubbles (MB) are established ultrasound (US) contrast agents.
  • MB are emerging as promising stimuli-responsive platforms for drug delivery.
  • Understanding drug physicochemical properties is crucial for optimizing MB-based delivery.

Purpose of the Study:

  • To investigate the impact of drug hydrophobicity and molecular weight on MB loading, stability, and release.
  • To evaluate the influence of drug structural similarity on these parameters.
  • To assess the US-triggered release efficiency across different drug-loaded MB formulations.

Main Methods:

  • Loading of eight model drugs (varying in hydrophobicity and molecular weight) into poly(butyl cyanoacrylate) (PBCA) MB.
  • Assessment of MB loading capacity, shelf-life stability, and US properties.
  • Evaluation of drug release kinetics and US-induced MB destruction.

Main Results:

  • For drugs with similar structures (corticosteroids), loading and release strongly correlated with hydrophobicity and molecular weight.
  • For structurally dissimilar drugs (fluorescent dyes), no clear correlation was observed.
  • All tested MB formulations exhibited efficient destruction upon US exposure.

Conclusions:

  • Physicochemical properties, particularly hydrophobicity and molecular weight, significantly influence drug loading and retention in polymeric MB.
  • Drug structural similarity plays a key role in predicting loading and release behavior.
  • These findings are vital for designing effective ultrasound-triggered drug delivery systems using MB.