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Preclinical SPECT and SPECT-CT in Oncology

Benjamin L Franc1, Youngho Seo2, Robert Flavell2

  • 1Department of Radiology, Stanford University School of Medicine, 300 Pasteur Drive, H2232, MC 5281, Stanford, CA, 94305-5105, USA. benster@stanford.edu.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|June 29, 2020
PubMed

Insights

Molecular imaging with single-photon emission tomography (SPECT) advances cancer research. SPECT and SPECT-CT systems, along with novel radiopharmaceuticals, offer enhanced sensitivity for studying carcinogenesis and evaluating cancer drugs in small animal models.

Area of Science:

  • Molecular imaging
  • Nuclear medicine
  • Oncology research

Background:

  • Molecular imaging provides spatial and temporal insights into carcinogenesis and cancer spread.
  • Single-photon emission tomography (SPECT) is a nuclear imaging technique suitable for in vivo studies in small animal models.
  • SPECT aids in drug discovery and characterization of antitumor effects and adverse events.

Purpose of the Study:

  • To highlight advances in small animal SPECT and SPECT-CT systems.
  • To showcase the evolution of SPECT radiopharmaceutical agents.
  • To discuss applications of SPECT in oncology and emerging research areas.

Main Methods:

  • Utilizing advanced small animal SPECT and SPECT-CT systems.
  • Employing a range of SPECT radiopharmaceutical agents.
  • In vivo studies in small animal models for carcinogenesis and drug evaluation.

Main Results:

  • Unprecedented sensitivity and quantitative molecular imaging capabilities achieved.
  • Demonstrated utility in studying complex biologic systems of cancer.
  • Enabled detailed characterization of drug candidates' antitumor actions and potential side effects.

Conclusions:

  • Advances in SPECT technology and radiopharmaceuticals significantly enhance molecular imaging in oncology.
  • SPECT is a powerful tool for in vivo research in small animal models, aiding cancer studies and drug development.
  • Ongoing exploration promises further innovative applications of SPECT in cancer research.

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