Related Experiment Video
Updated: Dec 17, 2025

Treatment with Locking Intramedullary Nailing for Intertrochanteric Fracture of the Femur Utilizing a New Awl with a Distal Positioner
Published on: June 6, 2025
TREATMENT OF HUMERAL SHAFT FRACTURES: ANTEGRADE INTERLOCKING INTRAMEDULLARY NAILING WITH ADDITIONAL INTERLOCKING
Dinko Vidović1, Ivan Benčić1, Tomislav Ćuti1
11Department of Traumatology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2Department of Surgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 3School of Dental Medicine, University of Zagreb, Zagreb, Croatia; 4School of Medicine, University of Zagreb, Zagreb, Croatia; 5School of Medicine, University of Split, Split, Croatia; 6University of Applied Health Sciences, Zagreb, Croatia; 7Orthopedic and Traumatology Department, Dubrovnik General Hospital, Dubrovnik, Croatia; 8Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.
This study found no significant difference in humeral shaft fracture healing time when using antegrade interlocking intramedullary nails with or without additional interlocking screws. The use of extra screws did not accelerate bone union in this patient cohort.
Area of Science:
- Orthopedic surgery
- Traumatology
- Biomedical engineering
Background:
- Humeral shaft fractures are common injuries.
- Intramedullary nailing is a standard treatment.
- The role of additional screws in promoting union is debated.
Purpose of the Study:
- To compare fracture union time between two antegrade interlocking intramedullary nail techniques for humeral shaft fractures.
- To evaluate the efficacy of additional interlocking neutralization screws in accelerating bone healing.
- To present the first clinical trial on this specific nail configuration.
Main Methods:
- Retrospective study of 51 patients with proximal and middle third humeral shaft fractures.
- Comparison between patients treated with antegrade intramedullary nail with (Group A) and without (Group B) additional interlocking screws.
- Radiographic assessment of union defined by cortical bridging.
Main Results:
- No statistically significant difference in union time was observed between the two groups (p>0.05).
- The addition of interlocking neutralization screws did not demonstrate a benefit in promoting faster bone union.
- This study represents the initial clinical investigation into this surgical approach.
Conclusions:
- The use of additional interlocking neutralization screws in antegrade intramedullary nailing for humeral shaft fractures does not appear to shorten union time.
- Hypothesized benefits of fracture gap reduction by these screws were not clinically confirmed.
- Further research may be warranted to explore potential indications or outcomes of this technique.

