Related Experiment Video
Updated: Dec 17, 2025
06:34
A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
10.3K
Different Development Forms of Local Allergic Rhinitis towards Birch.
Andrzej Bozek1, Janne Winterstein2, Beata Galuszka3
1Clinical Department of Internal Medicine, Dermatology and Allergology, Medical University of Silesia, Katowice, Poland.
Biomed Research International
|June 30, 2020
Summary
Allergen immunotherapy (AIT) effectively treats local allergic rhinitis (LAR) to birch pollen, improving symptoms and quality of life. It also shows promise in managing associated asthma symptoms in LAR patients.
Area of Science:
- Allergology and Immunology
- Respiratory Medicine
Background:
- Local allergic rhinitis (LAR) is increasingly recognized, with its treatment efficacy via allergen immunotherapy (AIT) being an emerging research area.
- The impact of AIT on patients with LAR who also exhibit asthmatic symptoms remains largely unexplored.
Purpose of the Study:
- To investigate the efficacy and safety of AIT for birch pollen-induced LAR.
- To examine the presence and impact of concomitant local allergic asthma in LAR patients undergoing AIT.
Main Methods:
- A three-year, double-blind, placebo-controlled study involving 36 patients with LAR to birch pollen.
- Primary outcomes included changes in combined symptom and medication scores (CSMSs) and quality of life (QoL).
- Diagnostic methods included skin prick tests, specific IgE, nasal and bronchial provocation challenges, methacholine tests, and spirometry.
Main Results:
- Significant reduction in mean CSMSs and improvement in QoL scores after three years of AIT.
- Increased allergen tolerance observed during nasal challenges, with significant reduction in bronchial responsiveness in patients with positive methacholine and bronchial challenge tests.
- AIT demonstrated significant benefits in reducing symptom burden and improving quality of life for patients with LAR.
Conclusions:
- AIT for birch pollen allergy is a safe and effective treatment for patients with local allergic rhinitis.
- AIT may also benefit patients with LAR experiencing concomitant asthmatic symptoms, warranting further investigation.
Related Concept Videos
02:06Allergic Reactions
31.6K
Overview
31.6K
01:20Asthma: Pathogenesis and Management
1.1K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.1K
01:27Allergic Drug Reactions
1.3K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.3K
01:26Asthma-II: Pathophysiology and Classification
3.9K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.9K
01:30Hypersensitivities
5.9K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
5.9K
01:23The Bronchial Tree
5.7K
The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
5.7K