Related Experiment Video
Updated: Dec 16, 2025
09:51
Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience
Published on: December 4, 2023
1.5K
Preoperative C-Reactive Protein/Albumin Ratio as a Predictive Factor for Gallbladder Carcinoma
Masashi Utsumi1, Hideki Aoki2, Seichi Nagahisa2
1Department of Surgery, National Hospital Organization, Iwakuni Clinical Center, Yamaguchi, Japan masashi11232001@yahoo.co.jp.
In Vivo (Athens, Greece)
|July 2, 2020
Summary
Preoperative C-reactive protein (CRP) to albumin ratio (CAR) can predict outcomes in gallbladder carcinoma (GBC) patients. A CAR of 0.07 or higher indicates poorer overall survival after GBC resection.
Area of Science:
- Oncology
- Surgical Oncology
- Biomarkers
Background:
- The C-reactive protein to albumin ratio (CAR) is linked to patient outcomes in sepsis.
- Gallbladder carcinoma (GBC) is a significant health concern requiring effective prognostic markers.
Purpose of the Study:
- To investigate the prognostic value of preoperative C-reactive protein to albumin ratio (CAR) in patients undergoing surgical resection for gallbladder carcinoma (GBC).
Main Methods:
- Retrospective analysis of 53 patients who underwent GBC resection between January 2008 and September 2019.
- Examined the correlation between preoperative CAR levels and overall survival (OS) and disease-free survival (DFS).
Main Results:
- An optimal cut-off CAR value of 0.07 was identified.
- Multivariate analysis revealed that R1/R2 resection, advanced tumor stage, CAR ≥ 0.07, and postoperative complications were independent predictors of OS.
- Higher carbohydrate antigen levels and R1/R2 resection were independent predictors of DFS.
Conclusions:
- Preoperative CAR serves as a significant independent predictor of long-term outcomes following GBC resection.
- Elevated preoperative CAR may indicate a higher risk of recurrence and poorer survival in GBC patients.
