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Updated: Dec 16, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Histopathological Features and Ann Arbor Stage in Periocular Lymphoma
Marco Zschoche1, Annette Zimpfer2, Björn O Scheef3
1Department of Ophthalmology, University Medical Center Rostock, Rostock, Germany vinodh.kakkassery@gmail.com marco.zschoche@gmail.com.
Background:
To evaluate biodata, symptoms/signs, lymphoma type, localization, stage level, treatment choice and outcome of ocular adnexal lymphoma (OAL).
Patients And Methods:
A single-center retrospective analysis of 56 patients with OAL was performed from 1998 to 2018.
Results:
OAL involved the orbit in 44.6%, the conjunctiva in 32.1%, the lacrimal apparatus in 14.3% and the eyelid in 8.93%. Extranodal marginal zone B-cell lymphoma (EMZL) was found in 60.7%, follicular lymphoma (FL) in 21.4%, diffuse large B-cell lymphoma in 7.14%, mantle cell lymphoma in 5.36% and chronic lymphatic leukaemia in 5.36% patients. No relapse was seen in 76%. EMZL and FL had a significantly better overall survival compared to other lymphoma types (p=0.002). Patients with Ann Arbor stage IE had a significantly better prognosis than those with stages higher than IE (p=0.048).
Conclusion:
Our data suggest that clinicopathological features such as Ann Arbor stage influence survival.
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