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An in vivo Comparison Study Between Strontium Nanoparticles and rhBMP2
Giulia Montagna1,2, Francesco Cristofaro1, Lorenzo Fassina2
1Department of Molecular Medicine (DMM), Center for Health Technologies (CHT), UdR INSTM, University of Pavia, Pavia, Italy.
Frontiers in Bioengineering and Biotechnology
|July 3, 2020
Summary
Strontium nanoparticles loaded onto Gelfoam sponges show superior bone regeneration compared to recombinant human bone morphogenetic protein 2 (rhBMP2). Strontium enhances osteoblast activity and inhibits osteoclasts, offering a promising non-biologic therapeutic for bone injuries.
Area of Science:
- Biomaterials Science
- Orthopedic Research
- Nanotechnology in Medicine
Background:
- Strontium exhibits proven osteoinductive properties, promoting bone formation and inhibiting bone resorption.
- Recombinant human bone morphogenetic protein 2 (rhBMP2) is an effective osteoinductive agent but has limitations due to its biological origin.
Purpose of the Study:
- To compare the osteoinductive efficacy of strontium-substituted hydroxyapatite nanoparticles against rhBMP2.
- To evaluate strontium nanoparticles as a non-biologic therapeutic for bone regeneration using Gelfoam sponges as carriers.
Main Methods:
- Gelfoam sponges were loaded with either rhBMP2 or strontium nanoparticles.
- Abiotic characterization of loaded sponges included ion release and structural analysis.
- In vivo studies involved implantation onto mouse periosteum, followed by histological and gene expression analysis.
Main Results:
- Strontium release from sponges was continuous over 28 days, mirroring rhBMP2 release patterns.
- Strontium induced stronger endochondral ossification and more potent osteoclast inhibition than rhBMP2.
- Histological and gene expression analyses confirmed strontium's superior bone regenerative potential.
Conclusions:
- Strontium nanoparticles delivered via Gelfoam sponges represent a novel, effective non-biologic bone graft alternative.
- This approach may offer improved outcomes for complex fractures and other bone defects.
- Strontium nanoparticles are a powerful therapeutic for bone regeneration.
