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The Contribution of Epigenetics to Cancer Immunotherapy
Lorea Villanueva1, Damiana Álvarez-Errico2, Manel Esteller3
1Josep Carreras Leukemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain; Centro de Investigación Biomédica en Red Cancer (CIBERONC), Madrid, Spain.
Trends in Immunology
|July 6, 2020
Summary
Epigenomic biomarkers show promise for predicting patient responses to cancer immunotherapy and guiding personalized treatment strategies. These epigenetic signatures can help improve treatment success and reduce adverse effects.
Area of Science:
- Oncology
- Immunology
- Epigenetics
Background:
- Anticancer immunotherapy offers significant advancements but faces challenges with patient response variability, relapse, and toxicity.
- Identifying reliable predictors of treatment success is crucial for optimizing cancer care.
Purpose of the Study:
- To provide a comprehensive overview of potential epigenetic biomarkers for cancer immunotherapy.
- To discuss the advantages of epigenetic biomarkers in patient stratification and precision medicine.
Main Methods:
- Review of current literature on epigenomic signatures and their role in immunotherapy response.
- Analysis of candidate epigenetic biomarkers for predicting patient outcomes.
Main Results:
- Epigenomic signatures in immune and cancer cells are promising predictors of immunotherapy outcomes.
- Epigenetic drugs may modulate responses to immunotherapy by targeting dynamic epigenetic changes.
Conclusions:
- Epigenetic biomarkers offer a powerful tool for patient stratification in immunotherapy.
- Utilizing epigenetic biomarkers can enhance treatment efficacy and minimize adverse events in precision oncology.
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