Concurrent Antisolvent Electrospraying: A Novel Continuous Crystallization Technique.

Area of Science:

• Pharmaceutical science
• Materials science
• Chemical engineering

Background:

• Pharmaceutical co-crystals (CCs) enhance drug properties like solubility and bioavailability.
• Industrial production of CCs faces challenges in scale-up, control, and batch processing.

Purpose of the Study:

• To introduce and evaluate a novel continuous manufacturing technique for pharmaceutical co-crystals.
• To demonstrate the efficacy of concurrent coaxial antisolvent electrospray (Co-E) for CC synthesis.

Main Methods:

• Implementation of a concurrent coaxial antisolvent electrospray (Co-E) system.
• Synthesis of co-crystals using three amino acid pairs as model compounds.
• Comparison of Co-E with traditional methods like antisolvent crystallization and grinding.

Main Results:

• Co-E facilitated rapid, continuous, and controlled synthesis of pharmaceutical co-crystals.
• The Co-E method produced CCs with desirable spherical morphology and enhanced formation.
• The technique demonstrated robustness against process variations, ensuring consistent product characteristics.

Conclusions:

• Concurrent coaxial antisolvent electrospray (Co-E) offers a viable alternative for reliable industrial production of pharmaceutical co-crystals.
• This continuous manufacturing approach addresses limitations of traditional batch methods.
• Co-E shows promise for the scalable synthesis of CCs and other pharmaceutical products.