A convenient approach by using poly-(HEMA-co-NIPAM)/Cu²⁺ solution sol-gel transition for wound protection and healing

Rapid and convenient wound healing is crucial for reducing potential post-traumatic wound complications. In this study, a temperature-sensitive polymer of poly-(HEMA-co-NIPAM) (PHN) was synthesized by free-radical polymerization, in which the solution quickly underwent a sol-gel transition above 29°C, thus responding to a typical body temperature and facilitating wound sealing. PHN solution incorporated with copper ions (PHN-Cu) not only exhibited excellent antibacterial properties, but also expedited wound closure and facilitated tissue angiogenesis. The in vivo and in vitro experiments showed that the PHN-Cu had a higher wound closure rate and demonstrated an ability to promote skin tissue angiogenesis. Such a versatile, convenient aqueous solution could enable nonprofessionals to promptly treat wounds in a short time after injury, thus providing suitable conditions for later treatment, and can be used as a convenient method to clean wounds.