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Microfluidic Technology for Nucleic Acid Aptamer Evolution and Application.

Lewis A Fraser1, Yee-Wai Cheung1, Andrew B Kinghorn1

  • 1School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong (SAR), China.

Advanced Biosystems
|July 7, 2020
PubMed
Summary
This summary is machine-generated.

Microfluidics enhances aptamer technology for diverse applications. This review covers microfluidic approaches, from capillary electrophoresis to micromagnetic beads, revolutionizing aptamer-based bioassays for diagnostics and biosensing.

Keywords:
SELEXaptamersbiosensorsmicrofluidicsselection

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Area of Science:

  • Biomedical Science
  • Analytical Chemistry
  • Biotechnology

Background:

  • Aptamer technology offers specific molecular recognition capabilities.
  • Microfluidics provides miniaturized platforms for biological assays.
  • Integrating these technologies promises enhanced bioanalytical performance.

Purpose of the Study:

  • To review the impact of microfluidics on aptamer applications.
  • To explore various microfluidic techniques used with aptamers.
  • To highlight the potential of microfluidic aptasensors in diagnostics and biosensing.

Main Methods:

  • Review of literature on microfluidics and aptamer integration.
  • Discussion of traditional methods like capillary electrophoresis.
  • Exploration of modern techniques including micromagnetic beads and emulsion droplets.

Main Results:

  • Microfluidics significantly advances aptamer-based assays.
  • Miniaturization leads to faster, more sensitive, and portable bioassays.
  • Diverse microfluidic strategies enhance aptamer performance and applicability.

Conclusions:

  • Microfluidics is a key enabling technology for aptamer development.
  • Microfluidic aptasensors hold transformative potential for point-of-care diagnostics.
  • Further integration will drive innovation in biosensing and biomedical science.