[Ultrastructural diagnosis of early neoplasia in man]

Recent progress in cancer detection technology has resulted in the increasing need for pathological diagnosis of small cancers at their early stage of development. Electron microscopy of early cancers may reveal ultrastructural markers characteristic of certain cell lineage and help classify these cancers in terms of aberration in differentiation of neoplastic cells. Furthermore, electron microscopy of early cancers may detect certain cellular gene products at cellular as well as subcellular levels, and help understand the process of malignant progression in situ of transformed cells.