Non-Autogenous Innovative Reconstruction Method Following Mandibulectomy.

Area of Science:

• Oral and Maxillofacial Surgery
• Regenerative Medicine
• Oncology

Background:

• Plexiform ameloblastoma is a rare, locally aggressive odontogenic tumor requiring wide surgical resection.
• Traditional mandible reconstruction often involves autografts or free flaps, aiming to restore function and aesthetics.
• Limited options exist for reconstruction, especially in the anterior mandible.

Observation:

• A 50-year-old male with a 2 cm anterior mandible ameloblastoma underwent resection.
• Reconstruction utilized an allogenic bone block, recombinant human bone morphogenetic protein (rhBMP), and xenograft particles.
• A transcutaneous submental approach was employed for the reconstruction.

Findings:

• This case demonstrates a unique reconstruction method for anterior mandible defects.
• The combination of allogenic bone, rhBMP, and xenograft facilitated bone maturation for subsequent dental implant placement.
• Successful restoration with fixed prosthetics was achieved post-bone maturation.

Implications:

• Allogenic bone combined with rhBMP and xenograft presents a viable alternative to autogenous bone for mandible reconstruction.
• The transcutaneous submental approach may enhance the success rate of these complex reconstruction procedures.
• Effective mandible reconstruction significantly impacts patient quality of life, function, and aesthetics.