Assessment of Gold Bio-Functionalization for Wide-Interface Biosensing Platforms

Area of Science:

• Bioelectronic devices
• Biosensing applications
• Biomarker quantification

Background:

• Clinical diagnosis requires multiplexed biomarker quantification from single samples.
• Lab-based electrolyte-gated thin-film transistor (EGTFT) devices need translation into portable, cost-effective prototypes.
• Optimizing bio-functionalization of the transistor gate is critical for manufacturability.

Discussion:

• Assessed a sustainable, cost-effective bio-functionalization process for gold surfaces using surface plasmon resonance (SPR).
• The optimized protocol reduces biorecognition element concentration by 90%.
• This significantly impacts manufacturing costs for wide-field bioelectronic sensors.

Key Insights:

• Achieved high analytical performance with drastically reduced manufacturing costs.
• Demonstrated a viable method for cost-effective bio-functionalization of EGTFT gate electrodes.
• Enables development of affordable, portable multiplexing bioelectronic sensor arrays.

Outlook:

• Facilitates the clinical translation of advanced bioelectronic sensors.
• Supports early disease detection and personalized medicine.
• Reduces healthcare expenses through improved diagnostic tools.