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Related Experiment Video

Updated: Dec 15, 2025

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

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Analysis of Factors Associated with Thyroid Dysfunction: A Hospital Based Study.

P Risal1, B Adhikari2, R Shrestha2

  • 1Department of Clinical Biochemistry, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.

Kathmandu University Medical Journal (KUMJ)
|July 8, 2020
PubMed
Summary

Thyroid dysfunction affects 35.3% of patients in Nepal, with subclinical hypothyroidism being most common. Direct pesticide exposure is linked to hypothyroidism, but other common risk factors showed no significant association.

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Area of Science:

  • Endocrinology
  • Public Health
  • Epidemiology

Background:

  • Thyroid dysfunction (TD) is a significant public health issue in Nepal.
  • Understanding TD prevalence and associated factors is crucial for targeted interventions.

Purpose of the Study:

  • To determine the hospital-based prevalence of thyroid dysfunction.
  • To identify and analyze factors associated with thyroid dysfunction in the Nepali population.

Main Methods:

  • A retroprospective, cross-sectional study involving 1530 subjects undergoing Thyroid Function Tests (TFTs).
  • Data collected via semi-structured questionnaires and anthropometric measurements from 312 participants.
  • Statistical analyses included Chi-square, Pearson's correlation, and student-t tests.

Main Results:

  • Overall thyroid dysfunction prevalence was 35.3%, with subclinical hypothyroidism at 24.8%.
  • Higher prevalence observed in females and older individuals, and among the Terai/Madhesi ethnic group.
  • Direct pesticide exposure was significantly associated with hypothyroidism; TSH correlated with waist-hip ratio, and weight with fT4.

Conclusions:

  • Thyroid dysfunction is highly prevalent in the studied population, predominantly subclinical hypothyroidism.
  • Direct pesticide exposure is a potential risk factor for hypothyroidism.
  • Established risk factors like smoking, alcoholism, diabetes, and hypertension were not significantly associated with TD in this cohort.