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Updated: Dec 15, 2025

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
Published on: May 24, 2020
New methodological approaches for assessing thrombus formation in cardiovascular disease
Kazuya Hosokawa1, Tomoko Ohnishi-Wada2, Tomoka Nagasato3
1Research Institute, Fujimori Kogyo Co., Ltd., Yokohama, Kanagawa, Japan. kazuya-hosokawa@zacros.co.jp
Abstract:
Antiplatelet therapy is the mainstay preventive strategy for cardiovascular diseases, and dual antiplatelet therapy comprising aspirin and a P2Y12 inhibitor is the standard treatment for patients who underwent percutaneous coronary intervention. The Total Thrombus‑Formation Analysis System (T‑TAS) is a microchip flow‑chamber system developed to evaluate overall thrombus formation under flow conditions, which is reportedly able to assess single and combined antithrombotic therapy. Here, we focus on this new system, T‑TAS, and review its characteristics together with those of the conventional systems available for evaluation of antithrombotic therapies for cardiovascular diseases.
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