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Updated: Dec 15, 2025
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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
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Interferons: role in cancer therapy
Mohadeseh Haji Abdolvahab1, Behrad Darvishi1, Mohammad Zarei2,3
1Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran 1517964311, Iran.
Immunotherapy
|July 9, 2020
Summary
Interferons (IFNs) are crucial cytokines for host defense against disease. While IFNs aid anti-tumor responses, their chronic signaling can paradoxically promote cancer therapy resistance, highlighting their complex role.
Area of Science:
- Immunology
- Molecular Biology
- Oncology
Background:
- Interferons (IFNs) are signaling cytokines produced by host cells to mediate protection against various disorders.
- IFNs exhibit dual roles, directly affecting tumor cells or activating the immune system for host defense.
- IFN expression and function are tightly regulated to prevent excessive host responses.
Purpose of the Study:
- To elucidate the intricate role of Interferons (IFNs) in cancer and immune cell interactions.
- To explore the correlation between IFN signaling and the efficacy of anticancer therapies.
- To identify the potential of understanding IFN mechanisms as a target for combination therapies.
Main Methods:
- Analysis of Interferon (IFN) expression levels in cancer and immune cells.
- Investigating the modulation of biological functions by IFNs in the context of cancer.
- Reviewing the impact of IFN signaling on the efficacy of various antineoplasm therapies.
Main Results:
- IFN signaling is integral to inducing antitumor immune responses.
- Chronic stimulation of IFN signaling pathways can lead to resistance against antineoplasm treatments.
- Both cancer and immune cells express IFNs, influencing their respective biological functions.
Conclusions:
- Understanding the complex mechanisms of Interferon (IFN) signaling is critical in cancer biology.
- The dual role of IFNs in promoting anti-tumor immunity and therapy resistance presents a therapeutic challenge.
- Targeting IFN pathways may offer a promising strategy for novel combination therapies in oncology.
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