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Pachydermoperiostosis with gastric hypertrophy, anemia, and increased serum bone Gla-protein levels
P Y Venencie1, G A Boffa, P D Delmas
1Unité de Dermatologie, Centre Hospitalier Universitaire, Bicêtre, France.
Archives of Dermatology
|December 1, 1988
Abstract:
We evaluated a patient in whom pachydermoperiostosis occurred in conjunction with anemia and gastric hypertrophy. The mechanism of the anemia appears multifactorial because, besides a myelofibrosis, a serum inhibitor of the late stage of erythropoiesis was detected. The elevated serum bone Gla-protein (osteocalcin) favors the hypothesis that primary hypertrophic osteoarthropathy represents an imbalance between increased osteoblastic bone formation and normal bone resorption.