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The interface between coronaviruses and host cell RNA biology: Novel potential insights for future therapeutic

David G Maranon1, John R Anderson1, Abril G Maranon1

  • 1Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.

Wiley Interdisciplinary Reviews. RNA
|July 9, 2020
PubMed

Insights

Coronaviruses hijack cellular RNA processes for infection. Understanding these interactions offers new insights into viral pathogenesis and potential antiviral therapies.

Area of Science:

  • Molecular Biology
  • Virology
  • RNA Biology

Background:

  • Coronaviruses are RNA viruses that significantly impact cellular RNA processes.
  • These viruses interact with critical RNA-related cellular mechanisms during infection.

Purpose of the Study:

  • To provide a comprehensive overview of coronavirus interactions with cellular RNA biology.
  • To explore how coronaviruses manipulate RNA processing, stability, and translation.

Main Methods:

  • Literature review of studies on coronavirus-host RNA interactions.
  • Analysis of RNA-related cellular processes affected by coronaviruses.

Main Results:

  • Coronaviruses engage with diverse RNA processes including capping, polyadenylation, and translation.
  • Viral strategies involve usurping or evading host RNA machinery.

Conclusions:

  • Understanding these viral-RNA interactions is key to deciphering pathogenesis.
  • Targeting these interactions presents novel therapeutic opportunities against coronaviruses.
Keywords:
RNA stabilitycoronavirusmiRNApolyadenylationtranslation

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