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Using different definitions affected the reported prevalence of neurodevelopmental impairment in children born very

Sirkku Setänen1, Ylva Fredriksson Kaul1, Martin Johansson1

  • 1Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Acta Paediatrica (Oslo, Norway : 1992)
|July 9, 2020
PubMed

Insights

Varying definitions significantly impact the reported prevalence of neurodevelopmental impairment (NDI) in very preterm children. Standardizing NDI definitions is crucial for accurate long-term follow-up comparisons.

Area of Science:

  • Pediatrics
  • Neuroscience
  • Developmental Biology

Background:

  • Preterm birth is associated with an increased risk of neurodevelopmental impairment (NDI).
  • Accurate assessment of NDI prevalence is essential for effective intervention and resource allocation.
  • Current literature shows considerable variability in how NDI is defined and reported in long-term follow-up studies.

Purpose of the Study:

  • To investigate the impact of different definitions on the reported prevalence of neurodevelopmental impairment (NDI) in children born very preterm.
  • To compare NDI prevalence in a cohort of very preterm children with a reference group of full-term born children.
  • To highlight the need for standardized definitions in NDI research.

Main Methods:

  • Assessed cognitive development and neurosensory impairments in 91 children born before 32 gestational weeks at 6.5 years of age.
  • Compared findings with a reference group of 67 full-term born children.
  • Reported NDI prevalence based on definitions from seven contemporary studies on very or extremely preterm infants.

Main Results:

  • The prevalence of severe NDI ranged from 2% to 23% based on the definition used.
  • Cognitive impairment prevalence varied from 2% to 16%, cerebral palsy from 0% to 9%, and severe visual impairment from 0% to 1%.
  • No cases of severe hearing impairment were observed.

Conclusions:

  • Significant variability in NDI definitions complicates the interpretation of prevalence data in very preterm children.
  • A lack of consensus in NDI definitions hinders cross-study comparisons and the understanding of long-term outcomes.
  • Establishing standardized NDI definitions is critical for advancing research and clinical practice in preterm infant follow-up.
Abstract

Keywords:
cerebral palsycognitive impairmenthearing impairmentlong-term follow-upvisual impairment

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