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Developmental Strategies of Curcumin Solid Dispersions for Enhancing Bioavailability.
Phuong H L Tran1, Thao T D Tran2,3
1Deakin University, Geelong Australia, School of Medicine, Melbourne, Vic, Australia
Anti-Cancer Agents in Medicinal Chemistry
|July 10, 2020
Summary
Curcumin
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Nanotechnology
Background:
- Curcumin exhibits therapeutic potential but suffers from poor solubility, stability, and bioavailability.
- These limitations hinder its efficacy, particularly in cancer treatment.
Purpose of the Study:
- To review and classify methods for preparing curcumin solid dispersions.
- To highlight strategies for enhancing curcumin drug delivery and stability.
- To discuss the role of nanotechnology in curcumin formulations.
Main Methods:
- Systematic review of literature on curcumin solid dispersion preparation techniques.
- Classification of solid dispersion systems based on formulation strategies.
- Analysis of studies incorporating advanced nanotechnologies.
Main Results:
- Solid dispersions are effective in improving curcumin bioavailability and stability.
- Various preparation techniques exist, with a need for clear classification.
- Nanoparticles play a significant role in advanced curcumin solid dispersion formulations.
Conclusions:
- This review provides a comprehensive overview of curcumin solid dispersion strategies.
- It serves as a guide for future research and clinical development of curcumin formulations.
- Understanding these methods is crucial for optimizing curcumin's therapeutic applications.
Keywords:
Solid dispersionbioavailabilitychemical stabilitydrug deliverynanoparticlepoorly water-soluble drugMore Related Videos
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