Recent synthesis of thietanes

Area of Science:

• Organic Chemistry
• Heterocyclic Chemistry

Background:

• Thietanes are vital four-membered aliphatic thiaheterocycles.
• They are key structural motifs in pharmaceuticals and biologically active compounds.
• Thietanes serve as versatile intermediates in organic synthesis.

Purpose of the Study:

• To provide a comprehensive review of synthetic methodologies for thietanes.
• To cover the period from 1966 to 2019.
• To highlight recent advancements in thietane synthesis.

Main Methods:

• Review of established synthetic routes including nucleophilic thioetherifications, cycloadditions, and rearrangements.
• Analysis of recently developed strategies for thietane backbone construction.
• Categorization of diverse synthetic approaches.

Main Results:

• Compilation of a wide array of synthetic methods for thietanes.
• Identification of efficient strategies for preparing thietanes and their derivatives.
• Overview of the evolution of thietane synthesis over five decades.

Conclusions:

• Thietane synthesis has seen significant development with diverse methods available.
• Recent strategies offer efficient pathways to thietanes and derivatives.
• This review consolidates knowledge on thietane construction for researchers.