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A Separation-Sensing Membrane Performing Precise Real-Time Serum Analysis During Blood Drawing.
Zhenyu Chu1, Wei Zhang1,2, Qiannan You1
1State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, NO.30 Puzhu Road(S), Nanjing, 211816, China.
Angewandte Chemie (International Ed. in English)
|July 11, 2020
Summary
This study introduces a novel membrane for continuous, real-time blood analysis, enabling faster and more accurate monitoring of vital clinical indices like glucose and lactate directly as blood is drawn.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Analytical Chemistry
Background:
- Current blood-assay methods provide limited, discrete data, hindering real-time monitoring of physiological analytes.
- Continuous online reporting of dynamic analyte fluctuations in human serum remains a significant challenge in clinical diagnostics.
Purpose of the Study:
- To develop a novel separation-sensing membrane for continuous, on-site analysis of serum analytes.
- To achieve rapid and accurate real-time monitoring of vital clinical indices during blood collection.
Main Methods:
- Fabrication of a heterogeneous-nanostructured membrane with a surface nanoporous layer for serum extraction.
- Integration of biosensing nanochannels for dynamic recognition of biotargets.
- Precise control over pore structure and nanoshape of biosensing crystals for enhanced performance.
Main Results:
- The developed membrane enables continuous testing of vital clinical indices as blood is drawn.
- Accurate and online glucose and lactate monitoring achieved within 1 minute, an order of magnitude faster than existing techniques.
- Demonstrated capability for detecting glutamate, transaminase, and cancer biomarkers by introducing various bio-recognizers.
Conclusions:
- The novel separation-sensing membrane offers a significant advancement in continuous, on-site blood analysis.
- This technology facilitates rapid, real-time monitoring of critical health indicators, improving diagnostic capabilities.
- The platform's versatility allows for the detection of a broad range of biomarkers for diverse medical conditions.
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