Volatile Compounds Are Involved in Cellular Crosstalk and Upregulation
Mamatha Serasanambati1, Yoav Y Broza1, Hossam Haick1,2,3
1Department of Chemical Engineering, Technion - Israel Institute of Technology, Technion City, Haifa, 3200003, Israel.
Advanced Biosystems
|July 11, 2020
Summary
Cancer cells communicate through volatile organic compounds (VOCs) emitted into the headspace. This novel long-distance cell-cell cross talk influences cancer growth and may aid early detection and therapy monitoring.
Area of Science:
- Biochemistry
- Cell Biology
- Cancer Research
Background:
- Cell-cell cross talk is crucial in cancer, impacting proliferation, differentiation, migration, and apoptosis.
- Current understanding of cell-cell communication primarily stems from proteomic and genomic studies.
Purpose of the Study:
- To identify and characterize a novel route of cell-cell cross talk between cancer cells.
- To investigate the role of volatile organic compounds (VOCs) in mediating this long-distance communication.
Main Methods:
- Single-cell and culture analysis to detect VOC emission from cancer cells.
- Analysis of VOCs exchanged between monocultures and co-cultures without physical contact.
- Chemical characterization of the identified VOCs.
Main Results:
- Upregulated cancer cells emit hundreds of volatile organic compounds (VOCs) into their headspace.
- A portion of these VOCs are exchanged between cells, influencing growth in monocultures and co-cultures.
- The chemical nature and composition of these communication-mediating VOCs were determined.
Conclusions:
- A new mechanism of long-distance cancer cell-cell cross talk via VOCs has been discovered.
- This VOC-mediated communication influences cancer cell behavior and growth dynamics.
- This finding offers potential for developing advanced early cancer detection and metastasis monitoring strategies.
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