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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

731
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
731
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

807
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
807
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

676
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
676
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

791
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
791
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

544
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
544
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

339
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
339

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Related Experiment Video

Updated: Dec 15, 2025

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
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[Stress and inflammatory bowel disease].

Peter Christopher Konturek1,2, Kathrin Konturek3, Yurdagül Zopf4

  • 1Thüringen-Klinik Saalfeld, Akademisches Lehrkrankenhaus der Universitätsklinik Jena, Deutschland. pkonturek@web.de.

MMW Fortschritte Der Medizin
|July 15, 2020
PubMed
Summary

Mechanisms like increased cytokines, gut dysbiosis, and stress impact inflammatory bowel disease (IBD) flare-ups. Effective stress management is crucial for successful IBD therapy.

Keywords:
IBDdysbiosisinflammatory bowel diseasesleep disorderstress

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Area of Science:

  • Gastroenterology
  • Immunology
  • Neuroscience

Background:

  • Inflammatory bowel disease (IBD) is a chronic condition influenced by multiple pathophysiological mechanisms.
  • Key factors negatively impacting IBD include pro-inflammatory cytokines, gut dysbiosis, and increased intestinal permeability.

Purpose of the Study:

  • To elucidate the multifaceted mechanisms contributing to the exacerbation of inflammatory bowel disease.
  • To highlight the role of central and peripheral factors in IBD pathogenesis.

Main Methods:

  • Review of existing literature on IBD pathogenesis.
  • Analysis of the interplay between immune, gastrointestinal, and central nervous system factors.

Main Results:

  • Increased pro-inflammatory cytokine release exacerbates intestinal inflammation.
  • Gut dysbiosis and increased intestinal barrier permeability contribute to IBD flares.
  • Central factors, including corticotropin-releasing factor (CRF) and altered pain processing, lead to anxiety and depression, worsening IBD symptoms.

Conclusions:

  • Multiple interconnected mechanisms drive IBD progression and acute flare-ups.
  • Stress management strategies are essential components of comprehensive IBD treatment plans.