Related Experiment Video
Updated: Dec 14, 2025
06:51
Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches
Published on: September 5, 2025
426
Early Renal Function Alterations in Renal Branches vs. Renal Fenestrations - A Dynamic Scintigraphy Based Prospective
Matteo Orrico1, Laura Cosma2, Maria Ricci2
1Department of Vascular Surgery, San Camillo-Forlanini Hospital, Rome, Italy; Department of Vascular Surgery, Policlinico Santa Maria alle Scotte, University of Siena, Italy.
Summary
Branches used in fenestrated and branched endovascular aneurysm repair (F/BEVAR) led to a significant early decrease in renal function compared to fenestrations alone. Renal function remained stable at one year post-procedure.
Area of Science:
- Vascular Surgery
- Nephrology
- Medical Imaging
Background:
- Fenestrated and branched endovascular aneurysm repair (F/BEVAR) is a complex procedure for treating complex aortic aneurysms.
- Assessing the impact of different renal artery repair configurations on kidney function is crucial for patient outcomes.
Purpose of the Study:
- To compare the early-phase renal function outcomes between fenestration and branch techniques in F/BEVAR.
- To evaluate the impact of renal artery bridging components on glomerular filtration rate (GFR).
Main Methods:
- Prospective study of 67 patients undergoing F/BEVAR from March 2018 to June 2019.
- Patients divided into fenestration and branch groups.
- Dynamic renal scintigraphy with 99mTc-DTPA performed pre-operatively, and at 3 months and 1 year post-operatively.
Main Results:
- Analysis included 135 kidneys; 63 in the fenestration group and 72 in the branch group.
- A greater mean decrease in GFR was observed at 3 months in the branch group (-23.4 mL/min) compared to the fenestration group (-6.0 mL/min).
- This GFR decrease persisted at one year, indicating sustained impact.
Conclusions:
- The use of branches for renal arteries in F/BEVAR is associated with a more pronounced early decline in GFR than fenestrations.
- Scintigraphic evidence suggests significant renal function alterations in the early phase following F/BEVAR with branches.
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