Related Experiment Video
Updated: Dec 14, 2025
Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
In Vitro Comparison of Several Methods for Initial Proximal Caries Detection
Veselina Todorova1, Ivan Filipov1, Reneta Petrova2
1Medical University of Plovdiv, Plovdiv, Bulgaria.
Introduction:
Initial proximal caries is both diagnostic and therapeutic challenge. The disadvantages of the conventional methods for caries detection and the development of technologies led to the creation of contemporary optical devices for early caries detection.
Aim:
In vitro comparison of the diagnostic accuracy of several methods for early proximal caries detection - visual-tactile, bitewing radiography and laser fluorescence device (DIAGNOdent pen).
Materials And Methods:
Fifty-eight proximal surfaces of extracted human permanent premolars and molars were examined by two examiners using visual inspection, bitewing radiography, DIAGNOdent with proximal contact, and DIAGNOdent directly in the lesion. Results were compared with the histological gold standard. Statistical analysis with ROC curve, sensitivity, specificity and diagnostic accuracy of each detection method was performed. Analysis was conducted in 3 diagnostic thresholds - initial, developed and advanced demineralization.
Results:
Sensitivity of visual inspection was 16%-33%, specificity 93.3%-100%, sensitivity of bitewing radiography 54%-67%, speci-ficity 93%-94%, sensitivity of DIAGNOdent with proximal surfaces in contact 88%-91%, specificity 79%-89%, sensitivity of DIAG-NOdent directly 89%-92.5%, specificity 81.29%-93%. The highest diagnostic accuracy, increasing with the rise of the level of demin-eralization, was shown by DIAGNOdent directly, followed by DIAGNOdent with proximal contact, bitewing radiography, and visual inspection with the lowest accuracy.
Conclusion:
The use of contemporary diagnostic devices significantly increases the possibility for early detection of proximal lesions. DIAGNOdent can be used as an adjunct to and increasing the diagnostic accuracy of the conventional caries detection methods.
