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Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine
Konstantinos Stamatopoulos1, Sharad Karandikar2, Mark Goldstein3
1School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Pharmaceutics
|July 17, 2020
Summary
A new Dynamic Colon Model (DCM) simulates human colon motion to study fluid and particle movement. Higher viscosity fluids show poor mixing but increased particle propulsion, aiding drug formulation design.
Area of Science:
- Gastroenterology
- Biomedical Engineering
- Pharmacokinetics
Background:
- Understanding colon hydrodynamics is crucial for drug delivery.
- Existing models lack the fidelity to capture complex colon wall motion and its effects.
Purpose of the Study:
- To develop and validate a biorelevant Dynamic Colon Model (DCM).
- To investigate the influence of fluid viscosity and wall motion on particle transport within the colon.
Main Methods:
- In vivo MRI for colon wall motion data.
- Positron Emission Tomography (PET) for fluid hydrodynamics.
- Positron Emission Particle Tracking (PEPT) for particle motion analysis.
Main Results:
- Higher viscosity fluids exhibited poor mixing but enhanced forward particle propulsion.
- Particle displacements in the DCM closely matched in vivo data.
- Floating particles showed increased velocity on the surface, indicating faster surface waves.
Conclusions:
- The DCM accurately simulates colon luminal dynamics.
- Fluid viscosity significantly impacts particle transport and mixing.
- This model can optimize drug formulation design for colonic delivery.
Keywords:
cine-MRIcolon motilitycolon-specific drug formulationsdissolutiondynamic colon model (DCM)in vitro modelsmagnetic resonance imaging (MRI)positron emission tomography (PET)
