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Durvalumab-induced Immune-related Hepatitis in a Patient with Non-small Cell Lung Cancer

Masakatsu Nakamura¹, Toshimi Otsuka¹, Ranji Hayashi¹

¹Department of Gastroenterology, Kanazawa Medical University, Japan.

Internal Medicine (Tokyo, Japan)

|July 17, 2020

Abstract:

We herein report the case of a 79-year-old patient with unresectable stage III non-small cell lung cancer who developed immune-related hepatitis caused by durvalumab administration. Durvalumab was administered at 10 mg/kg every two weeks after the treatment with carboplatin (AUC2), paclitaxel (35 mg/m²), and 60 Gy radiation. At the day 208 in which the 14th durvalumab administration was scheduled, the patient was urgently hospitalized due to CTCAE Grade 4 hepatic dysfunction detected during the an outpatient blood sampling test. He was diagnosed with immune-related hepatitis and started on methylprednisolone 60 mg/day. After 51 days, his liver dysfunction improved and he was discharged.

Keywords:

durvalumab immune-related hepatitis non-small cell lung cancer

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