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Related Concept Videos

Development of the Heart01:27

Development of the Heart

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The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
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The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
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Related Experiment Video

Updated: Dec 14, 2025

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
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En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

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Engineering Heart Morphogenesis.

Christian J Mandrycky1, Nisa P Williams1, Ivan Batalov1

  • 1Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA; Department of Bioengineering, University of Washington, Seattle, WA, USA.

Trends in Biotechnology
|July 17, 2020
PubMed
Summary
This summary is machine-generated.

Engineers can now build a linear heart tube in vitro. This engineered tube can then be guided through cardiac looping, mimicking natural heart development for tissue engineering applications.

Keywords:
biomaterialsheart tube loopingmechanobiologyorganogenesisstem cellstissue engineering

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Area of Science:

  • Developmental biology
  • Tissue engineering
  • Cardiac morphogenesis

Background:

  • Stem cell biology and tissue engineering have advanced significantly, enabling complex tissue construction.
  • Cardiac development involves heart tube looping, transforming a simple tube into a four-chambered organ.

Purpose of the Study:

  • To propose recapitulating cardiac morphogenesis in vitro using current tissue engineering technologies.
  • To re-examine heart tube looping from an engineering perspective, highlighting the linear tube as a viable starting point.

Main Methods:

  • Review and synthesis of existing knowledge on heart tube looping.
  • Analysis of structures, signaling pathways, and mechanical stresses involved in cardiac looping.
  • Evaluation of potential approaches for engineering a linear heart tube and directing its looping.

Main Results:

  • The linear heart tube is identified as an advantageous structure for tissue engineering.
  • Key developmental factors influencing heart looping are summarized.
  • Potential engineering strategies for creating and manipulating a looping heart tube are discussed.

Conclusions:

  • Tissue engineering technologies are sufficiently advanced to tackle the challenge of in vitro cardiac morphogenesis.
  • The linear heart tube presents a promising foundation for engineering a developing heart.
  • Further research should focus on developing methods to build and guide the looping process in engineered heart tubes.