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Updated: Dec 14, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
The nested block preconditioning technique for the incompressible Navier-Stokes equations with emphasis on
Ju Liu1, Weiguang Yang1, Melody Dong1
1Department of Pediatrics (Cardiology), Department of Bioengineering, and Institute for Computational and Mathematical Engineering, Stanford University, Clark Center E1.3, 318 Campus Drive, Stanford, CA 94305, USA.
Abstract:
We develop a novel iterative solution method for the incompressible Navier-Stokes equations with boundary conditions coupled with reduced models. The iterative algorithm is designed based on the variational multiscale formulation and the generalized-α scheme. The spatiotemporal discretization leads to a block structure of the resulting consistent tangent matrix in the Newton-Raphson procedure. As a generalization of the conventional block preconditioners, a three-level nested block preconditioner is introduced to attain a better representation of the Schur complement, which plays a key role in the overall algorithm robustness and efficiency. This approach provides a flexible, algorithmic way to handle the Schur complement for problems involving multiscale and multiphysics coupling. The solution method is implemented and benchmarked against experimental data from the nozzle challenge problem issued by the US Food and Drug Administration. The robustness, efficiency, and parallel scalability of the proposed technique are then examined in several settings, including moderately high Reynolds number flows and physiological flows with strong resistance effect due to coupled downstream vasculature models. Two patient-specific hemodynamic simulations, covering systemic and pulmonary flows, are performed to further corroborate the efficacy of the proposed methodology.
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