Related Experiment Video
Updated: Dec 14, 2025
08:41
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
3.2K
SARS-CoV-2: Should We Be Concerned about the Nervous System?
Marcus Tulius T Silva1,2, Marco Lima1,3, Abelardo Q-C Araujo1,3
11Brazilian Ministry of Health, Evandro Chagas National Institute of Infectious Diseases (INI), Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
The American Journal of Tropical Medicine and Hygiene
|July 20, 2020
Summary
The COVID-19 pandemic impacts global health and economies. This review examines the potential neurological effects and neuropathogenesis of coronavirus disease 2019 (COVID-19) in patients.
Area of Science:
- Neurology
- Infectious Diseases
- Public Health
Background:
- The COVID-19 pandemic presents significant global health and economic challenges.
- While primarily respiratory, COVID-19 (caused by SARS-CoV-2) can affect multiple organs.
- Neurological manifestations of COVID-19 are underreported but crucial given prior coronavirus disease (CoV) studies.
Purpose of the Study:
- To review the potential neuropathogenesis of SARS-CoV-2.
- To describe the neurological profile of patients with COVID-19.
- To emphasize the importance of recognizing neurological complications.
Main Methods:
- Literature review of existing studies on COVID-19 and neurological aspects.
- Analysis of reported neurological manifestations in COVID-19 patients.
- Examination of potential neurotropic, neuroinvasive, and neurovirulent properties of SARS-CoV-2.
Main Results:
- Previous human CoVs (e.g., SARS-CoV, MERS-CoV) have demonstrated neurotropic, neuroinvasive, and neurovirulent capabilities.
- Neurological symptoms have been documented as complications in prior CoV outbreaks.
- Early reports suggest a range of neurological issues in COVID-19 patients.
Conclusions:
- Physicians must be vigilant for early signs of neurological compromise in COVID-19 patients.
- Clinical protocols are needed to systematically investigate neurological involvement.
- Understanding neuropathogenesis is vital for managing COVID-19 complications.
Related Concept Videos
01:28Disorders of the Nervous Tissue
2.3K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
2.3K
01:25What is a Nervous System?
103.5K
Overview
103.5K
01:21Nervous System
3.1K
The nervous system coordinates body functions through its complex network of nerve cells, enabling sensation and movement. It is divided into two primary parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and the spinal cord. The brain acts as the body's control center, processing sensory information and coordinating responses. The spinal cord functions as a major signaling pathway for the brain and the rest of the body.
3.1K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.9K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.9K
01:13Organization of the Nervous System
9.2K
The nervous system is one of the most complex systems in our body. It is organized into two main divisions: the central nervous system (CNS) and the peripheral nervous system (PNS).
The CNS, comprising the brain and spinal cord, houses billions of neurons. The brain is housed in the skull, while the spinal cord is linked to the brain through the foramen magnum of the occipital bone and is surrounded by the protective structure of the vertebral column. It is responsible for processing various...
The CNS, comprising the brain and spinal cord, houses billions of neurons. The brain is housed in the skull, while the spinal cord is linked to the brain through the foramen magnum of the occipital bone and is surrounded by the protective structure of the vertebral column. It is responsible for processing various...
9.2K
01:18Functions of the Nervous System
6.5K
The nervous system is responsible for coordinating and regulating the body's functions. It functions through three main processes: sensory, integrative, and motor processes. Sensory function involves the detection and transmission of information about internal and external stimuli from sensory receptors to the CNS. The CNS processes this information through an integrative function, where it interprets and makes decisions based on the incoming sensory information. Finally, the motor function...
6.5K